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Authored by two leading investigators, this book presents a thorough and authoritative overview of this multifaceted field of science. Pathogenic bacteria have been evolving and spreading resistance to diverse classes of antibiotics. As a result, we risk losing our ability to control and treat infectious diseases. Understanding antibiotic resistance, therefore, is becoming increasingly essential for a broad audience of healthcare professionals, biomedical and public health researchers, students, and policymakers. The authors answer questions such as: What is resistance? How does it emerge? How do common human activities contribute to resistance? What can we do about it? How can we strengthen our “first lines of defense” against resistance? Are there better ways to discover new antibiotics? What unique issues are associated with MRSA and viral influenza? In addition to defining and evaluating one of the most important emerging threats to public health, the authors explain what can be done to minimize risks to public health, and to preserve and extend the effectiveness of existing and new antibiotics.
- Sales Rank: #1039385 in Books
- Published on: 2011-02-19
- Original language: English
- Number of items: 1
- Dimensions: 10.32" h x .95" w x 7.20" l, 1.45 pounds
- Binding: Hardcover
- 288 pages
From the Back Cover
The emergence and spread of antibiotic resistance is a growing medical and public health emergency. Misuse and overuse of antibiotics is putting us at risk of losing our ability to cure infectious diseases. Karl Drlica and David S. Perlin give an authoritative and thorough explanation of all aspects of antibiotic resistance, from the basic science to the strategies that could minimize resistance problems and extend the life spans of existing antibiotic agents. Intended as the definitive book on a major biomedical issue, Antibiotic Resistance will be required reading for investigators and serious students in microbiology, infectious disease, pharmaceutics, and public health; physicians; and students in pharmacy, medicine, and veterinary medicine.
About the Author
Karl Drlica, Ph.D. is a Principal Investigator at the Public Health Research Institute and Professor of Microbiology & Molecular Genetics at the UMDNJ–New Jersey Medical School in Newark. His laboratory focuses on fluoroquinolone action and resistance with Mycobacteriun tuberculosis and other bacteria, including approaches for slowing the enrichment and amplification of resistant bacterial subpopulations.
David S. Perlin, Ph.D. is Executive Director of the Public Health Research Institute and UMDNJ Regional Biocontainment Laboratory, as well as Professor of Microbiology & Molecular Genetics at the New Jersey Medical School in Newark. He is also a Fellow of the New York Academy of Sciences. Dr. Perlin’s laboratory explores mechanisms of antifungal drug-resistance, rapid detection of drug resistant bloodstream pathogens in high-risk patients, and the application of small-animal models for the study of respiratory pathogens.
Most helpful customer reviews
8 of 8 people found the following review helpful.
readable for a layman. too fundamental for experts
By reviewer
Having finished the book in one sitting, I flipped back to the preface in search of what its targeted audience is. It was "initially drafted to supplement studies of infectious disease" and the authors later "aim to make the principles of antibiotic use and effectiveness available to a large audience: farmers, hospital administrators.....and especially individual users."
The book's content and style of writing serves well for the above targeted audience. The book is suitable for use at a high school or college freshman year level as a supplement. Interesting historical facts and social ramifications interspersed throughout the book. The book is light on the academic or theoretical side of it, probably intentionally so. It touches on biological mechanisms just enough to make a layman understand what they want to tell next, nothing more. Nonetheless, this book is a laudable attempt to educate the public about the subject.
3 of 3 people found the following review helpful.
Antibiotic Use: Cause and Effect
By M. A. Ramos
The authors outline and explain a problem that is not new but is starting to be brought into the public light. This book is written for people who use antibiotics and is written at an introductory yet clear level. The paramedics, farmers, hospital administrators and especially the public at large should read this book. If you do not have a background in basic biology the authors have included two appendix that give the basic background required to understand the rest of the text and I would recommend starting there.
The book is well presented on how the medical and agricultural use of antibiotics and their misuse has lead to pathogens mutating and becoming antibiotic resistance. And at present dosage and actually overuse of antibiotics will lead to a pathogen that will cause a pandemic. When is not discussed but when you read that rate at which the resistance strain mutate and spread it seems that this should be a subject of high priority. Yet pharmaceutical companies have been shutting down their antibiotic research division for it is not cost effective for them to continue.
The book is informative and not an alarmist manifesto. It covers the facts of use and history of antibiotics and present day measures. And proposes how we may be able to stop this path to a super resistant pathogen; a term not used by the authors. Most people know that the effectiveness of any type of drug diminishes with use and in low dosage the pathogens themselves become resistant. In order to rectify this situation will take a change of culture for all involved; farmers, medical professionals and moist important the general public. At present the authors show that all we are doing at present to slow down the spread and creation of antibiotic resistant pathogens is to increase dosage levels. These increased dosages may have more side effects but avoid the spread of the resistant pathogens.
I highly recommend that this book be read by medical practitioner, farmers and anyone who uses antibiotics. This is a very easy and interesting read.
4 of 5 people found the following review helpful.
First strike is still deadly
By haskpts
Antibiotic resistance is the ability of a microorganism to withstand the effects of an antibiotic.
Antibiotic resistance evolves naturally via natural selection through random mutation, but it could also be engineered by applying an evolutionary stress on a population. Antibiotic resistance is a consequence of evolution via natural selection.
Once such a gene is generated, bacteria can then transfer the genetic information in a horizontal fashion (between individuals) by plasmid exchange. "Antibiotic Resistance: Understanding And Responding To An Emerging Crisis" explains the concept of multiresistant organisms (aka; a "Superbug").
Bacteria which have a mutation allowing them to survive antibiotic intervention will live on to reproduce; passing on this resistance to their offspring in the next generation
Drlica & Perlin point out that the patterns of antibiotic usage greatly affect the number of resistant organisms which develop. Overuse of broad-spectrum antibiotics, such as second- and third-generation cephalosporins, greatly hastens the development of methicillin resistance.
Other factors contributing towards resistance include incorrect diagnosis, unnecessary prescriptions, improper use of antibiotics by patients, and the use of antibiotics as livestock food additives for growth promotion.
The book has the classic hallmarks of becoming a desktop reference for the clinician and those interested in new emerging bio-hazardous threats. I found the glossary very helpful and also the "light" and playful arrangement of facts an figures made the book enjoyable NOT another bland, boring "for scientists only". The layout reminded me of the "... For Dummies" and "The Complete Idiot's Guide To..." books. Which is a good thing. Comprehension of materials is the main point. No use having very dry, stuffy and hard to read or follow books ... which end up covered in dust and cobwebs for their unreadability.
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